IMPRESS Fellowship Project

Co-electrospun Membrane for Pelvic Floor Repair

UniOfLeeds
  • Principal Investigator

    University of Leeds

  • Co-Investigators

    Dr. Pete Culmer, School of Mechanical Engineering, University of Leeds

    Dr Richard Day, University College London

    Dr Tausif Muhammad, School of Design, University of Leeds

    Prof. Stephen Russell, School of Design, University of Leeds

Summary

This research project is undertaken as part of the IMPRESS Research Fellowship position, held by Dr Elena Mancuso. It has been developed through close collaboration with textiles experts at Leeds University and aims to design and construct a three dimensional (3D) membrane, via a needleless electrospinning technique, as a potential platform for the repair and regeneration of the human pelvic floor.

Pelvic organ prolapse (POP) is a common chronic disorder, occurring in up to 50% of women above the age of 50. Synthetic and natural materials are currently used for the treatment and repair of POP. However, there are still unmet clinical needs in terms of biocompatibility, mechanical properties, failure, infections and high recurrence risks. Specifically, synthetic polymers are prone to erosion and infection, while natural polymers have a rapid degradation rate with weak mechanical properties, thus their clinical application is limited. To address the current challenges, the aim of this work is to develop a biodegradable membrane that by mimicking the three-dimensional architecture of the pelvic floor, can allow a better biomechanical integration into the host tissue and then its repair.

Incontinence Management & PRevention through Engineering and ScienceS