IMPRESSplus call 2017 funded projects

OAB Fingerprint

PORTSMOUTHuni
SouthamptonNHS
  • Principal Investigator

    Dr John Young, Reader in Translational Medicine, University of Portsmouth

  • Co-Investigators

    Dr Sepinoud Firouzmand, University of Portsmouth
    Dr Louise Butt, University of Portsmouth
    Prof Brian Birch, Urologist, University Hospital Southampton
    Prof Anastasia Callaghan, Biochemistry & Molecular Biophysics, University of Portsmouth

Summary

The OAB Fingerprint project aims to develop a new diagnostic tool specific to Overactive Bladder (OAB) which affects one in five adults and is one of the most common causes of urinary incontinence. It builds on the recent discovery that five biomarker molecules in combination together create a ‘OAB fingerprint’ which is specific to the urine of patients with OAB.

Currently the gold standard procedure for diagnosis of OAB is an expensive and invasive technique called cystometry that ultimately fails to detect OAB in half of patients. The aim of this research is to develop an alternative non-invasive technique which can be used routinely at the point-of-care setting. This work will involve creating a biosensor that is capable of simultaneous detection of the five biomarker molecules within the urine and then determining the biosensor’s sensitivity and specificity.

Incontinence Management & PRevention through Engineering and ScienceS