Follow On Funding Project

Pelvic Nerve Stimulation to Control Urinary Incontinence

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  • Principal Investigator

    University of Bristol

  • Co-Investigators

    University of Aarhus, Denmark

Summary

With preliminary funding from IMPRESS we showed in urethane-anaesthetised rats that high frequency stimulation of the pelvic nerve could block urinary voiding that was induced every few minutes by continuous infusion of saline in the bladder.

The next stage will be to adopt a model that more closely resembles humans. The pig is ideal in this respect. Initially we will carry out a proof of concept study under terminal anaesthesia to replicate the findings in rats. We will investigate the effectiveness of high frequency pelvic nerve stimulation on voiding activity evoked by infusion of saline into the bladder.  We will conduct this work in collaboration with urological colleagues in the Department of Clinical Medicine, University of Aarhus, Denmark who have expertise in pig work.

Incontinence Management & PRevention through Engineering and ScienceS